Augmentin tissue penetration
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As these bone concentration/serum concentration ratios change over time, they are a suboptimal measure of the extent of tissue penetration (36, 47). A single dose of 2, mg amoxicillin in combination with mg clavulanic acid ( Augmentin; GlaxoSmithKline, Munich, Germany) was administered as a short- term.
Description:We present the first evaluation of the bone penetration of a beta-lactam by population pharmacokinetics and pharmacodynamic profiling via Monte Carlo simulations. Blood and bone specimens were collected. Bone samples were pulverized under liquid nitrogen with a cryogenic mill, including an internal standard. The drug concentrations in serum and total bone were analyzed by liquid chromatography-tandem mass spectrometry. The equilibration half-lives between serum and bone were 12 min for amoxicillin and 14 min for clavulanic acid. The AUC of amoxicillin-clavulanic acid was 5 to 10 times lower in bone than in serum, and amoxicillin-clavulanic acid achieved a rapid equilibrium and favorable population PTAs against pathogens commonly encountered in bone infections.